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Psychedelics Psilocybin also produced a decrease in PPI at short ISIs that is correlated with impaired attention and consistent with deficient PPI in schizophrenia. Following up on these promising results, the same group tested the ability of R-DOI to block the inflammatory effects of TNF-α in the whole animal (Nau et al., 2013). Saline, R-DOI (0.01, 0.1, or 0.3 μg/kg), and TNF-α (10 mg/kg) were administered intraperitoneally to C57BL/6J mice, with R-DOI given 30 minutes prior to TNF-α. The highest dose of R-DOI administered in that study (0.3 mg/kg) is the lowest dose that can be behaviorally detected by mice (Smith et al., 2003). R-DOI was found to block TNF-α–induced increases of these inflammatory markers in the vasculature . In the intestine, the lowest amount of drug (0.01 mg/kg) produced a maximal anti-inflammatory effect and nearly completely blocked the expression of all proinflammatory markers examined. Sunness described a 15-year-old female patient with a 2-year history o